Publikationen

Publikationen

(2012) Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers.

Antoniou, A.C., K.B. Kuchenbaecker, P. Soucy, J. Beesley, X. Chen, L. McGuffog, A. Lee, D. Barrowdale, S. Healey, O.M. Sinilnikova, M.A. Caligo, N. Loman, K. Harbst, A. Lindblom, B. Arver, R. Rosenquist, P. Karlsson, K. Nathanson, S. Domchek, T. Rebbeck, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, E. Zlowowcka-Perlowska, A. Osorio, M. Duran, R. Andres, J. Benitez, U. Hamann, F.B. Hogervorst, T.A. van Os, S. Verhoef, H.E. Meijers-Heijboer, J. Wijnen, E.B. Gomez Garcia, M.J. Ligtenberg, M. Kriege, J.M. Collee, M.G. Ausems, J.C. Oosterwijk, S. Peock, D. Frost, S.D. Ellis, R. Platte, E. Fineberg, D.G. Evans, F. Lalloo, C. Jacobs, R. Eeles, J. Adlard, R. Davidson, T. Cole, J. Cook, J. Paterson, F. Douglas, C. Brewer, S. Hodgson, P.J. Morrison, L. Walker, M.T. Rogers, A. Donaldson, H. Dorkins, A.K. Godwin, B. Bove, D. Stoppa-Lyonnet, C. Houdayer, B. Buecher, A. de Pauw, S. Mazoyer, A. Calender, M. Leone, B. Bressac-de Paillerets, O. Caron, H. Sobol, M. Frenay, F. Prieur, S.U. Ferrer, I. Mortemousque, S. Buys, M. Daly, A. Miron, M.U. Terry, J.L. Hopper, E.M. John, M. Southey, D. Goldgar, C.F. Singer, A. Fink-Retter, M.K. Tea, D.U. Kaulich, T.V. Hansen, F.C. Nielsen, R.B. Barkardottir, M. Gaudet, T. Kirchhoff, V. Joseph, A. Dutra-Clarke, K. Offit, M. Piedmonte, J. Kirk, D. Cohn, J. Hurteau, J. Byron, J. Fiorica, A.E. Toland, M. Montagna, C. Oliani, E. Imyanitov, C. Isaacs, L. Tihomirova, I. Blanco, C. Lazaro, A. Teule, J.D. Valle, S.A. Gayther, K. Odunsi, J. Gross, B.Y. Karlan, E. Olah, S.H. Teo, P.A. Ganz, M.S. Beattie, C.M. Dorfling, E.U. van Rensburg, O. Diez, A. Kwong, R.K. Schmutzler, B. Wappenschmidt, C. Engel, A. Meindl, N. Ditsch, N. Arnold, S. Heidemann, D. Niederacher, S. Preisler-Adams, D. Gadzicki, R. Varon-Mateeva, H. Deissler, A. Gehrig, C. Sutter, K. Kast, B. Fiebig, D. Schafer, T. Caldes, M. de la Hoya, H. Nevanlinna, T.A. Muranen, B. Lesperance, A.B. Spurdle, S.L. Neuhausen, Y.C. Ding, X. Wang, Z. Fredericksen, V.S. Pankratz, N.M. Lindor, P. Peterlongo, S. Manoukian, B. Peissel, D. Zaffaroni, B. Bonanni, L. Bernard, R. Dolcetti, L. Papi, L. Ottini, P. Radice, M.H. Greene, J.T. Loud, I.L. Andrulis, H. Ozcelik, A.U. Mulligan, G. Glendon, M. Thomassen, A.M. Gerdes, U.B. Jensen, A.B. Skytte, T.A. Kruse, G. Chenevix-Trench, F.J. Couch, J. Simard, D.F. Easton, S.-B. Cimba, Hebon, Embrace, G.C. Study and I. kConFab. Breast Cancer Res, 14(1): p. R33.

(2012) A 24-color metaphase-based radiation assay discriminates heterozygous BRCA2 mutation carriers from controls by chromosomal radiosensitivity.

Becker, A.A., M.K. Graeser, C. Landwehr, T. Hilger, W. Baus, B. Wappenschmidt, A. Meindl, R.G. Weber, and R.K. Schmutzler. Breast Cancer Res Treat, 135(1): p. 167-75.

(2012) Genetic variants within miR-126 and miR-335 are not associates with breast cancer risk.

Bojesen SE, S.R.e.a.. Breast Cancer Res and Treat, in press.

Consortium of Investigators of Modifiers of (2012) Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.

Couch, F.J., M.M. Gaudet, A.C. Antoniou, S.J. Ramus, K.B. Kuchenbaecker, P. Soucy, J. Beesley, X. Chen, X. Wang, T. Kirchhoff, L. McGuffog, D. Barrowdale, A. Lee, S. Healey, O.M. Sinilnikova, I.L. Andrulis, Ocgn, H. Ozcelik, A.M. Mulligan, M. Thomassen, A.M. Gerdes, U.B. Jensen, A.B. Skytte, T.A. Kruse, M.A. Caligo, A. von Wachenfeldt, G. Barbany-Bustinza, N. Loman, M. Soller, H. Ehrencrona, P. Karlsson, B. Swe, K.L. Nathanson, T.R. Rebbeck, S.M. Domchek, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, E. Zlowocka, T. Huzarski, T. Byrski, J. Gronwald, C. Cybulski, B. Gorski, A. Osorio, M. Duran, M.I. Tejada, J. Benitez, U. Hamann, F.B. Hogervorst, Hebon, T.A. van Os, F.E. van Leeuwen, H.E. Meijers-Heijboer, J. Wijnen, M.J. Blok, M. Kets, M.J. Hooning, R.A. Oldenburg, M.G. Ausems, S. Peock, D. Frost, S.D. Ellis, R. Platte, E. Fineberg, D.G. Evans, C. Jacobs, R.A. Eeles, J. Adlard, R. Davidson, D.M. Eccles, T. Cole, J. Cook, J. Paterson, C. Brewer, F. Douglas, S.V. Hodgson, P.J. Morrison, L. Walker, M.E. Porteous, M.J. Kennedy, L.E. Side, Embrace, B. Bove, A.K. Godwin, D. Stoppa-Lyonnet, G.S. Collaborators, M. Fassy-Colcombet, L. Castera, F. Cornelis, S. Mazoyer, M. Leone, N. Boutry-Kryza, B. Bressac-de Paillerets, O. Caron, P. Pujol, I. Coupier, C. Delnatte, L. Akloul, H.T. Lynch, C.L. Snyder, S.S. Buys, M.B. Daly, M. Terry, W.K. Chung, E.M. John, A. Miron, M.C. Southey, J.L. Hopper, D.E. Goldgar, C.F. Singer, C. Rappaport, M.K. Tea, A. Fink-Retter, T.V. Hansen, F.C. Nielsen, A. Arason, J. Vijai, S. Shah, K. Sarrel, M.E. Robson, M. Piedmonte, K. Phillips, J. Basil, W.S. Rubinstein, J. Boggess, K. Wakeley, A. Ewart-Toland, M. Montagna, S. Agata, E.N. Imyanitov, C. Isaacs, R. Janavicius, C. Lazaro, I. Blanco, L. Feliubadalo, J. Brunet, S.A. Gayther, P.P. Pharoah, K.O. Odunsi, B.Y. Karlan, C.S. Walsh, E. Olah, S.H. Teo, P.A. Ganz, M.S. Beattie, E.J. van Rensburg, C.M. Dorfling, O. Diez, A. Kwong, R.K. Schmutzler, B. Wappenschmidt, C. Engel, A. Meindl, N. Ditsch, N. Arnold, S. Heidemann, D. Niederacher, S. Preisler-Adams, D. Gadzicki, R. Varon-Mateeva, H. Deissler, A. Gehrig, C. Sutter, K. Kast, B. Fiebig, W. Heinritz, T. Caldes, M. de la Hoya, T.A. Muranen, H. Nevanlinna, M.D. Tischkowitz, A.B. Spurdle, S.L. Neuhausen, Y.C. Ding, N.M. Lindor, Z. Fredericksen, V.S. Pankratz, P. Peterlongo, S. Manoukian, B. Peissel, D. Zaffaroni, M. Barile, L. Bernard, A. Viel, G. Giannini, L. Varesco, P. Radice, M.H. Greene, P.L. Mai, D.F. Easton, G. Chenevix-Trench, i. kConFab, K. Offit, J. Simard and B.. Cancer Epidemiol Biomarkers Prev, 21(4): p. 645-57.

(2012) Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk.

Couch, F.S., RK et al.. PLoS Genet, accepted.

(2012) Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.

Dick, M.G., B. Versmold, C. Engel, A. Meindl, N. Arnold, R. Varon-Mateeva, C. Sutter, D. Niederacher, H. Deissler, S. Preisler-Adams, K. Kast, D. Schafer, D. Gadzicki, W. Heinritz, B. Wappenschmidt, and R.K. Schmutzler. Int J Cancer, 130(6): p. 1314-8.

Consortium of Investigators of Modifiers of (2012) A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.

Ding, Y.C., L. McGuffog, S. Healey, E. Friedman, Y. Laitman, S. Paluch-Shimon, B. Kaufman, B. Swe, A. Liljegren, A. Lindblom, H. Olsson, U. Kristoffersson, M. Stenmark-Askmalm, B. Melin, S.M. Domchek, K.L. Nathanson, T.R. Rebbeck, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, J. Gronwald, T. Huzarski, C. Cybulski, T. Byrski, A. Osorio, T.R. Cajal, A.V. Stavropoulou, J. Benitez, U. Hamann, Hebon, M. Rookus, C.M. Aalfs, J.L. de Lange, H.E. Meijers-Heijboer, J.C. Oosterwijk, C.J. van Asperen, E.B. Gomez Garcia, N. Hoogerbrugge, A. Jager, R.B. van der Luijt, Embrace, D.F. Easton, S. Peock, D. Frost, S.D. Ellis, R. Platte, E. Fineberg, D.G. Evans, F. Lalloo, L. Izatt, R. Eeles, J. Adlard, R. Davidson, D. Eccles, T. Cole, J. Cook, C. Brewer, M. Tischkowitz, A.K. Godwin, H. Pathak, G.S. Collaborators, D. Stoppa-Lyonnet, O.M. Sinilnikova, S. Mazoyer, L. Barjhoux, M. Leone, M. Gauthier-Villars, V. Caux-Moncoutier, A. de Pauw, A. Hardouin, P. Berthet, H. Dreyfus, S.F. Ferrer, M.A. Collonge-Rame, J. Sokolowska, S. Buys, M. Daly, A. Miron, M.B. Terry, W. Chung, E.M. John, M. Southey, D. Goldgar, C.F. Singer, M.K. Tea, D. Gschwantler-Kaulich, A. Fink-Retter, T.V. Hansen, B. Ejlertsen, O.T. Johannsson, K. Offit, K. Sarrel, M.M. Gaudet, J. Vijai, M. Robson, M.R. Piedmonte, L. Andrews, D. Cohn, L.R. DeMars, P. DiSilvestro, G. Rodriguez, A.E. Toland, M. Montagna, S. Agata, E. Imyanitov, C. Isaacs, R. Janavicius, C. Lazaro, I. Blanco, S.J. Ramus, L. Sucheston, B.Y. Karlan, J. Gross, P.A. Ganz, M.S. Beattie, R.K. Schmutzler, B. Wappenschmidt, A. Meindl, N. Arnold, D. Niederacher, S. Preisler-Adams, D. Gadzicki, R. Varon-Mateeva, H. Deissler, A. Gehrig, C. Sutter, K. Kast, H. Nevanlinna, K. Aittomaki, J. Simard, K.C. Investigators, A.B. Spurdle, J. Beesley, X. Chen, G.E. Tomlinson, J. Weitzel, J.E. Garber, O.I. Olopade, W.S. Rubinstein, N. Tung, J.L. Blum, S.A. Narod, S. Brummel, D.L. Gillen, N. Lindor, Z. Fredericksen, V.S. Pankratz, F.J. Couch, P. Radice, P. Peterlongo, M.H. Greene, J.T. Loud, P.L. Mai, I.L. Andrulis, G. Glendon, H. Ozcelik, Ocgn, A.M. Gerdes, M. Thomassen, U.B. Jensen, A.B. Skytte, M.A. Caligo, A. Lee, G. Chenevix-Trench, A.C. Antoniou, S.L. Neuhausen and B.. Cancer Epidemiol Biomarkers Prev, 21(8): p. 1362-70.

(2012) BRCA1/2 testing: uptake, phenocopies, and strategies to improve detection rates in initially negative families.

Fischer, C., C. Engel, C. Sutter, S. Zachariae, R. Schmutzler, A. Meindl, S. Heidemann, T. Grimm, T. Goecke, I. Debatin, D. Horn, P. Wieacker, D. Gadzicki, K. Becker, D. Schafer, F. Stock, T. Voigtlander, B. on behalf of the German Consortium for Hereditary, and C. Ovarian. Clin Genet, 82(5): p. 478-483.

(2012) Genome-wide association studies identify four ER-negative specific breast cancer risk loci.

Garcia-Closas M, S.R.e.a.. Nature Genetics, accepted.

(2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci.

Ghoussaini, M., O. Fletcher, K. Michailidou, C. Turnbull, M.K. Schmidt, E. Dicks, J. Dennis, Q. Wang, M.K. Humphreys, C. Luccarini, C. Baynes, D. Conroy, M. Maranian, S. Ahmed, K. Driver, N. Johnson, N. Orr, I. dos Santos Silva, Q. Waisfisz, H. Meijers-Heijboer, A.G. Uitterlinden, F. Rivadeneira, B. Netherlands Collaborative Group on Hereditary, C. Ovarian, P. Hall, K. Czene, A. Irwanto, J. Liu, H. Nevanlinna, K. Aittomaki, C. Blomqvist, A. Meindl, R.K. Schmutzler, B. Muller-Myhsok, P. Lichtner, J. Chang-Claude, R. Hein, S. Nickels, D. Flesch-Janys, H. Tsimiklis, E. Makalic, D. Schmidt, M. Bui, J.L. Hopper, C. Apicella, D.J. Park, M. Southey, D.J. Hunter, S.J. Chanock, A. Broeks, S. Verhoef, F.B. Hogervorst, P.A. Fasching, M.P. Lux, M.W. Beckmann, A.B. Ekici, E. Sawyer, I. Tomlinson, M. Kerin, F. Marme, A. Schneeweiss, C. Sohn, B. Burwinkel, P. Guenel, T. Truong, E. Cordina-Duverger, F. Menegaux, S.E. Bojesen, B.G. Nordestgaard, S.F. Nielsen, H. Flyger, R.L. Milne, M.R. Alonso, A. Gonzalez-Neira, J. Benitez, H. Anton-Culver, A. Ziogas, L. Bernstein, C.C. Dur, H. Brenner, H. Muller, V. Arndt, C. Stegmaier, S. Familial Breast Cancer, C. Justenhoven, H. Brauch, T. Bruning, N. Gene Environment Interaction of Breast Cancer in Germany, S. Wang-Gohrke, U. Eilber, T. Dork, P. Schurmann, M. Bremer, P. Hillemanns, N.V. Bogdanova, N.N. Antonenkova, Y.I. Rogov, J.H. Karstens, M. Bermisheva, D. Prokofieva, E. Khusnutdinova, A. Lindblom, S. Margolin, A. Mannermaa, V. Kataja, V.M. Kosma, J.M. Hartikainen, D. Lambrechts, B.T. Yesilyurt, G. Floris, K. Leunen, S. Manoukian, B. Bonanni, S. Fortuzzi, P. Peterlongo, F.J. Couch, X. Wang, K. Stevens, A. Lee, G.G. Giles, L. Baglietto, G. Severi, C. McLean, G.G. Alnaes, V. Kristensen, A.L. Borrensen-Dale, E.M. John, A. Miron, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, S. Kauppila, I.L. Andrulis, G. Glendon, A.M. Mulligan, P. Devilee, C.J. van Asperen, R.A. Tollenaar, C. Seynaeve, J.D. Figueroa, M. Garcia-Closas, L. Brinton, J. Lissowska, M.J. Hooning, A. Hollestelle, R.A. Oldenburg, A.M. van den Ouweland, A. Cox, M.W. Reed, M. Shah, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, M. Jones, M. Schoemaker, A. Ashworth, A. Swerdlow, J. Beesley, X. Chen, I. kConFab, G. Australian Ovarian Cancer Study, K.R. Muir, A. Lophatananon, S. Rattanamongkongul, A. Chaiwerawattana, D. Kang, K.Y. Yoo, D.Y. Noh, C.Y. Shen, J.C. Yu, P.E. Wu, C.N. Hsiung, A. Perkins, R. Swann, L. Velentzis, D.M. Eccles, W.J. Tapper, S.M. Gerty, N.J. Graham, B.A. Ponder, G. Chenevix-Trench, P.D. Pharoah, M. Lathrop, A.M. Dunning, N. Rahman, J. Peto and D.F. Easton. Nat Genet, 44(3): p. 312-8.

(2012) Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.

Heidemann, S., C. Fischer, C. Engel, B. Fischer, L. Harder, B. Schlegelberger, D. Niederacher, T.O. Goecke, S.C. Doelken, N. Dikow, W. Jonat, S. Morlot, R.C. Schmutzler, and N.K. Arnold. Breast Cancer Res Treat, 134(3): p. 1229-39.

(2012) Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).

Hein, R., M. Maranian, J.L. Hopper, M.K. Kapuscinski, M.C. Southey, D.J. Park, M.K. Schmidt, A. Broeks, F.B. Hogervorst, H.B. Bueno-de-Mesquit, K.R. Muir, A. Lophatananon, S. Rattanamongkongul, P. Puttawibul, P.A. Fasching, A. Hein, A.B. Ekici, M.W. Beckmann, O. Fletcher, N. Johnson, I. dos Santos Silva, J. Peto, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, F. Marmee, A. Schneeweiss, C. Sohn, B. Burwinkel, P. Guenel, E. Cordina-Duverger, F. Menegaux, T. Truong, S.E. Bojesen, B.G. Nordestgaard, H. Flyger, R.L. Milne, J.I. Perez, M.P. Zamora, J. Benitez, H. Anton-Culver, A. Ziogas, L. Bernstein, C.A. Clarke, H. Brenner, H. Muller, V. Arndt, C. Stegmaier, N. Rahman, S. Seal, C. Turnbull, A. Renwick, A. Meindl, S. Schott, C.R. Bartram, R.K. Schmutzler, H. Brauch, U. Hamann, Y.D. Ko, G. Network, S. Wang-Gohrke, T. Dork, P. Schurmann, J.H. Karstens, P. Hillemanns, H. Nevanlinna, T. Heikkinen, K. Aittomaki, C. Blomqvist, N.V. Bogdanova, I.V. Zalutsky, N.N. Antonenkova, M. Bermisheva, D. Prokovieva, A. Farahtdinova, E. Khusnutdinova, A. Lindblom, S. Margolin, A. Mannermaa, V. Kataja, V.M. Kosma, J. Hartikainen, X. Chen, J. Beesley, I. Kconfab, A. Group, D. Lambrechts, H. Zhao, P. Neven, H. Wildiers, S. Nickels, D. Flesch-Janys, P. Radice, P. Peterlongo, S. Manoukian, M. Barile, F.J. Couch, J.E. Olson, X. Wang, Z. Fredericksen, G.G. Giles, L. Baglietto, C.A. McLean, G. Severi, K. Offit, M. Robson, M.M. Gaudet, J. Vijai, G.G. Alnaes, V. Kristensen, A.L. Borresen-Dale, E.M. John, A. Miron, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, M. Grip, I.L. Andrulis, J.A. Knight, G. Glendon, A.M. Mulligan, J.D. Figueroa, M. Garcia-Closas, J. Lissowska, M.E. Sherman, M. Hooning, J.W. Martens, C. Seynaeve, M. Collee, P. Hall, K. Humpreys, K. Czene, J. Liu, A. Cox, I.W. Brock, S.S. Cross, M.W. Reed, S. Ahmed, M. Ghoussaini, P.D. Pharoah, D. Kang, K.Y. Yoo, D.Y. Noh, A. Jakubowska, K. Jaworska, K. Durda, E. Zlowocka, S. Sangrajrang, V. Gaborieau, P. Brennan, J. McKay, C.Y. Shen, J.C. Yu, H.M. Hsu, M.F. Hou, N. Orr, M. Schoemaker, A. Ashworth, A. Swerdlow, A. Trentham-Dietz, P.A. Newcomb, L. Titus, K.M. Egan, G. Chenevix-Trench, A.C. Antoniou, M.K. Humphreys, J. Morrison, J. Chang-Claude, D.F. Easton and A.M. Dunning. PLoS One, 7(8): p. e42380.

(2012) Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

Kirchhoff, T., M.M. Gaudet, A.C. Antoniou, L. McGuffog, M.K. Humphreys, A.M. Dunning, S.E. Bojesen, B.G. Nordestgaard, H. Flyger, D. Kang, K.Y. Yoo, D.Y. Noh, S.H. Ahn, T. Dork, P. Schurmann, J.H. Karstens, P. Hillemanns, F.J. Couch, J. Olson, C. Vachon, X. Wang, A. Cox, I. Brock, G. Elliott, M.W. Reed, B. Burwinkel, A. Meindl, H. Brauch, U. Hamann, Y.D. Ko, G. Network, A. Broeks, M.K. Schmidt, L.J. Van 't Veer, L.M. Braaf, N. Johnson, O. Fletcher, L. Gibson, J. Peto, C. Turnbull, S. Seal, A. Renwick, N. Rahman, P.E. Wu, J.C. Yu, C.N. Hsiung, C.Y. Shen, M.C. Southey, J.L. Hopper, F. Hammet, T. Van Dorpe, A.S. Dieudonne, S. Hatse, D. Lambrechts, I.L. Andrulis, N. Bogdanova, N. Antonenkova, J.I. Rogov, D. Prokofieva, M. Bermisheva, E. Khusnutdinova, C.J. van Asperen, R.A. Tollenaar, M.J. Hooning, P. Devilee, S. Margolin, A. Lindblom, R.L. Milne, J.I. Arias, M.P. Zamora, J. Benitez, G. Severi, L. Baglietto, G.G. Giles, kConFab, A.S. Group, A.B. Spurdle, J. Beesley, X. Chen, H. Holland, S. Healey, S. Wang-Gohrke, J. Chang-Claude, A. Mannermaa, V.M. Kosma, J. Kauppinen, V. Kataja, B.A. Agnarsson, M.A. Caligo, A.K. Godwin, H. Nevanlinna, T. Heikkinen, Z. Fredericksen, N. Lindor, K.L. Nathanson, S.M. Domchek, B. Swe, N. Loman, P. Karlsson, M. Stenmark Askmalm, B. Melin, A. von Wachenfeldt, Hebon, F.B. Hogervorst, M. Verheus, M.A. Rookus, C. Seynaeve, R.A. Oldenburg, M.J. Ligtenberg, M.G. Ausems, C.M. Aalfs, H.J. Gille, J.T. Wijnen, E.B. Gomez Garcia, Embrace, S. Peock, M. Cook, C.T. Oliver, D. Frost, C. Luccarini, G. Pichert, R. Davidson, C. Chu, D. Eccles, K.R. Ong, J. Cook, F. Douglas, S. Hodgson, D.G. Evans, R. Eeles, B. Gold, P.D. Pharoah, K. Offit, G. Chenevix-Trench, D.F. Easton and Bcac/Cimba. PLoS One, 7(6): p. e35706.

(2012) The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers.

Laitman, Y., K.B. Kuchenbaecker, J. Rantala, F. Hogervorst, S. Peock, A.K. Godwin, A. Arason, T. Kirchhoff, K. Offit, C. Isaacs, R.K. Schmutzler, B. Wappenschmidt, H. Nevanlinna, X. Chen, G. Chenevix-Trench, S. Healey, F. Couch, P. Peterlongo, P. Radice, K.L. Nathanson, M.A. Caligo, S.L. Neuhausen, P. Ganz, O.M. Sinilnikova, L. McGuffog, D.F. Easton, A.C. Antoniou, I. Wolf, and E. Friedman. Breast Cancer Res Treat, 132(3): p. 1119-26.

(2012) 11q13 is a susceptibility locus for hormone receptor positive breast cancer.

Lambrechts, D., T. Truong, C. Justenhoven, M.K. Humphreys, J. Wang, J.L. Hopper, G.S. Dite, C. Apicella, M.C. Southey, M.K. Schmidt, A. Broeks, S. Cornelissen, R. van Hien, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, R.L. Milne, M.P. Zamora, J.I. Perez, J. Benitez, U. Hamann, Y.D. Ko, T. Bruning, G. Network, J. Chang-Claude, U. Eilber, R. Hein, S. Nickels, D. Flesch-Janys, S. Wang-Gohrke, E.M. John, A. Miron, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, M. Grip, G. Chenevix-Trench, J. Beesley, X. Chen, k. Investigators, G. Australian Ovarian Cancer Study, F. Menegaux, E. Cordina-Duverger, C.Y. Shen, J.C. Yu, P.E. Wu, M.F. Hou, I.L. Andrulis, T. Selander, G. Glendon, A.M. Mulligan, H. Anton-Culver, A. Ziogas, K.R. Muir, A. Lophatananon, S. Rattanamongkongul, P. Puttawibul, M. Jones, N. Orr, A. Ashworth, A. Swerdlow, G. Severi, L. Baglietto, G. Giles, M. Southey, F. Marme, A. Schneeweiss, C. Sohn, B. Burwinkel, B.T. Yesilyurt, P. Neven, R. Paridaens, H. Wildiers, H. Brenner, H. Muller, V. Arndt, C. Stegmaier, A. Meindl, S. Schott, C.R. Bartram, R.K. Schmutzler, A. Cox, I.W. Brock, G. Elliott, S.S. Cross, P.A. Fasching, R. Schulz-Wendtland, A.B. Ekici, M.W. Beckmann, O. Fletcher, N. Johnson, S. Silva Idos, J. Peto, H. Nevanlinna, T.A. Muranen, K. Aittomaki, C. Blomqvist, T. Dork, P. Schurmann, M. Bremer, P. Hillemanns, N.V. Bogdanova, N.N. Antonenkova, Y.I. Rogov, J.H. Karstens, E. Khusnutdinova, M. Bermisheva, D. Prokofieva, S. Gancev, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, B.G. Nordestgaard, S.E. Bojesen, C. Lanng, A. Mannermaa, V. Kataja, V.M. Kosma, J.M. Hartikainen, P. Radice, P. Peterlongo, S. Manoukian, L. Bernard, F.J. Couch, J.E. Olson, X. Wang, Z. Fredericksen, G.G. Alnaes, V. Kristensen, A.L. Borresen-Dale, P. Devilee, R.A. Tollenaar, C.M. Seynaeve, M.J. Hooning, M. Garcia-Closas, S.J. Chanock, J. Lissowska, M.E. Sherman, P. Hall, J. Liu, K. Czene, D. Kang, K.Y. Yoo, D.Y. Noh, A. Lindblom, S. Margolin, A.M. Dunning, P.D. Pharoah, D.F. Easton, P. Guenel and H. Brauch. Hum Mutat, 33(7): p. 1123-32.

Consortium of Investigators of Modifiers of (2012) Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Mavaddat, N., D. Barrowdale, I.L. Andrulis, S.M. Domchek, D. Eccles, H. Nevanlinna, S.J. Ramus, A. Spurdle, M. Robson, M. Sherman, A.M. Mulligan, F.J. Couch, C. Engel, L. McGuffog, S. Healey, O.M. Sinilnikova, M.C. Southey, M.B. Terry, D. Goldgar, F. O'Malley, E.M. John, R. Janavicius, L. Tihomirova, T.V. Hansen, F.C. Nielsen, A. Osorio, A. Stavropoulou, J. Benitez, S. Manoukian, B. Peissel, M. Barile, S. Volorio, B. Pasini, R. Dolcetti, A.L. Putignano, L. Ottini, P. Radice, U. Hamann, M.U. Rashid, F.B. Hogervorst, M. Kriege, R.B. van der Luijt, Hebon, S. Peock, D. Frost, D.G. Evans, C. Brewer, L. Walker, M.T. Rogers, L.E. Side, C. Houghton, Embrace, J. Weaver, A.K. Godwin, R.K. Schmutzler, B. Wappenschmidt, A. Meindl, K. Kast, N. Arnold, D. Niederacher, C. Sutter, H. Deissler, D. Gadzicki, S. Preisler-Adams, R. Varon-Mateeva, I. Schonbuchner, H. Gevensleben, D. Stoppa-Lyonnet, M. Belotti, L. Barjhoux, G.S. Collaborators, C. Isaacs, B.N. Peshkin, T. Caldes, M. de la Hoya, C. Canadas, T. Heikkinen, P. Heikkila, K. Aittomaki, I. Blanco, C. Lazaro, J. Brunet, B.A. Agnarsson, A. Arason, R.B. Barkardottir, M. Dumont, J. Simard, M. Montagna, S. Agata, E. D'Andrea, M. Yan, S. Fox, I. kConFab, T.R. Rebbeck, W. Rubinstein, N. Tung, J.E. Garber, X. Wang, Z. Fredericksen, V.S. Pankratz, N.M. Lindor, C. Szabo, K. Offit, R. Sakr, M.M. Gaudet, C.F. Singer, M.K. Tea, C. Rappaport, P.L. Mai, M.H. Greene, A. Sokolenko, E. Imyanitov, A.E. Toland, L. Senter, K. Sweet, M. Thomassen, A.M. Gerdes, T. Kruse, M. Caligo, P. Aretini, J. Rantala, A. von Wachenfeld, K. Henriksson, S.-B. Collaborators, L. Steele, S.L. Neuhausen, R. Nussbaum, M. Beattie, K. Odunsi, L. Sucheston, S.A. Gayther, K. Nathanson, J. Gross, C. Walsh, B. Karlan, G. Chenevix-Trench, D.F. Easton, A.C. Antoniou and B.. Cancer Epidemiol Biomarkers Prev, 21(1): p. 134-47.

 

(2012) Large-scale genotyping identifies 38 new breast cancer susceptibility loci. Submitted.

Michailidou K, S.R.e.a.. Nature Genetics.

(2012) Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families.

Osorio, A., D. Endt, F. Fernandez, K. Eirich, M. de la Hoya, R. Schmutzler, T. Caldes, A. Meindl, D. Schindler, and J. Benitez. Hum Mol Genet, 21(13): p. 2889-98.

Consortium of Investigators of Modifiers of (2012) Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.

Ramus, S.J., A.C. Antoniou, K.B. Kuchenbaecker, P. Soucy, J. Beesley, X. Chen, L. McGuffog, O.M. Sinilnikova, S. Healey, D. Barrowdale, A. Lee, M. Thomassen, A.M. Gerdes, T.A. Kruse, U.B. Jensen, A.B. Skytte, M.A. Caligo, A. Liljegren, A. Lindblom, H. Olsson, U. Kristoffersson, M. Stenmark-Askmalm, B. Melin, B. Swe, S.M. Domchek, K.L. Nathanson, T.R. Rebbeck, A. Jakubowska, J. Lubinski, K. Jaworska, K. Durda, E. Zlowocka, J. Gronwald, T. Huzarski, T. Byrski, C. Cybulski, A. Toloczko-Grabarek, A. Osorio, J. Benitez, M. Duran, M.I. Tejada, U. Hamann, M. Rookus, F.E. van Leeuwen, C.M. Aalfs, H.E. Meijers-Heijboer, C.J. van Asperen, K.E. van Roozendaal, N. Hoogerbrugge, J.M. Collee, M. Kriege, R.B. van der Luijt, Hebon, Embrace, S. Peock, D. Frost, S.D. Ellis, R. Platte, E. Fineberg, D.G. Evans, F. Lalloo, C. Jacobs, R. Eeles, J. Adlard, R. Davidson, D. Eccles, T. Cole, J. Cook, J. Paterson, F. Douglas, C. Brewer, S. Hodgson, P.J. Morrison, L. Walker, M.E. Porteous, M.J. Kennedy, H. Pathak, A.K. Godwin, D. Stoppa-Lyonnet, V. Caux-Moncoutier, A. de Pauw, M. Gauthier-Villars, S. Mazoyer, M. Leone, A. Calender, C. Lasset, V. Bonadona, A. Hardouin, P. Berthet, Y.J. Bignon, N. Uhrhammer, L. Faivre, C. Loustalot, Gemo, S. Buys, M. Daly, A. Miron, M.B. Terry, W.K. Chung, E.M. John, M. Southey, D. Goldgar, C.F. Singer, M.K. Tea, G. Pfeiler, A. Fink-Retter, T. Hansen, B. Ejlertsen, O.T. Johannsson, K. Offit, T. Kirchhoff, M.M. Gaudet, J. Vijai, M. Robson, M. Piedmonte, K.A. Phillips, L. Van Le, J.S. Hoffman, A. Ewart Toland, M. Montagna, S. Tognazzo, E. Imyanitov, C. Issacs, R. Janavicius, C. Lazaro, I. Blanco, E. Tornero, M. Navarro, K.B. Moysich, B.Y. Karlan, J. Gross, E. Olah, T. Vaszko, S.H. Teo, P.A. Ganz, M.S. Beattie, C.M. Dorfling, E.J. van Rensburg, O. Diez, A. Kwong, R.K. Schmutzler, B. Wappenschmidt, C. Engel, A. Meindl, N. Ditsch, N. Arnold, S. Heidemann, D. Niederacher, S. Preisler-Adams, D. Gadzicki, R. Varon-Mateeva, H. Deissler, A. Gehrig, C. Sutter, K. Kast, B. Fiebig, D. Schafer, T. Caldes, M. de la Hoya, H. Nevanlinna, K. Aittomaki, M. Plante, A.B. Spurdle, kConFab, S.L. Neuhausen, Y.C. Ding, X. Wang, N. Lindor, Z. Fredericksen, V.S. Pankratz, P. Peterlongo, S. Manoukian, B. Peissel, D. Zaffaroni, B. Bonanni, L. Bernard, R. Dolcetti, L. Papi, L. Ottini, P. Radice, M.H. Greene, P.L. Mai, I.L. Andrulis, G. Glendon, H. Ozcelik, Ocgn, P.D. Pharoah, S.A. Gayther, J. Simard, D.F. Easton, F.J. Couch, G. Chenevix-Trench and B.. Hum Mutat, 33(4): p. 690-702.

(2012) The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1 or BRCA2 positive families: a retrospective cohort study.

Rhiem, K., C. Engel, M. Graeser, S. Zachariae, K. Kast, M. Kiechle, N. Ditsch, W. Janni, C. Mundhenke, M. Golatta, D. Varga, S. Preisler-Adams, T. Heinrich, U. Bick, D. Gadzicki, S. Briest, A. Meindl, and R.K. Schmutzler. Breast Cancer Res, 14(6): p. R156.

(2012) The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1- or BRCA2- positive families : a retrospective cohort study.

Rhiem K, E.C., Graeser M … Schmutzler RK. In press. Breast Cancer Research

(2012) Risk-reducing surgery in women at risk for familial breast and ovarian cancer.

Rhiem K, P.K., Schmutzler RK, Kiechle M. Geburtshilfe und Frauenheilkunde 72: p. 833-9.

(2012) Hoffnung und Fluch der Genanalyse.

Rhiem K, S.R. (2012) Neue Aspekte in der Therapie des familiären Mamma- und Ovarialkarzinoms. Onkologische Pharmazie 14: p. 10-5.Schmutzler RK, D.D., Jöckel K-H. Deutsches Ärzteblatt 26: p. 1371-5.

(2012) Hoffnung und Fluch der Genanalyse.

Schmutzler RK, D.D., Jöckel K-H. Deutsches Ärzteblatt 26: p. 1371-5.

(2012) A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.

Siddiq, A., F.J. Couch, G.K. Chen, S. Lindstrom, D. Eccles, R.C. Millikan, K. Michailidou, D.O. Stram, L. Beckmann, S. Kyong Rhie, C.B. Ambrosone, K. Aittomaki, P. Amiano, C. Apicella, I. Australian Breast Cancer Tissue Bank, L. Baglietto, E.V. Bandera, M.W. Beckmann, C.D. Berg, L. Bernstein, C. Blomqvist, H. Brauch, L. Brinton, Q.M. Bui, J.E. Buring, S.S. Buys, D. Campa, J.E. Carpenter, D.I. Chasman, J. Chang-Claude, C. Chen, F. Clavel-Chapelon, A. Cox, S.S. Cross, K. Czene, S.L. Deming, R.B. Diasio, W.R. Diver, A.M. Dunning, L. Durcan, A.B. Ekici, P.A. Fasching, S. Familial Breast Cancer, H.S. Feigelson, L. Fejerman, J.D. Figueroa, O. Fletcher, D. Flesch-Janys, M.M. Gaudet, G.C. The, S.M. Gerty, J.L. Rodriguez-Gil, G.G. Giles, C.H. van Gils, A.K. Godwin, N. Graham, D. Greco, P. Hall, S.E. Hankinson, A. Hartmann, R. Hein, J. Heinz, R.N. Hoover, J.L. Hopper, J.J. Hu, S. Huntsman, S.A. Ingles, A. Irwanto, C. Isaacs, K.B. Jacobs, E.M. John, C. Justenhoven, R. Kaaks, L.N. Kolonel, G.A. Coetzee, M. Lathrop, L. Le Marchand, A.M. Lee, I.M. Lee, T. Lesnick, P. Lichtner, J. Liu, E. Lund, E. Makalic, N.G. Martin, C.A. McLean, H. Meijers-Heijboer, A. Meindl, P. Miron, K.R. Monroe, G.W. Montgomery, B. Muller-Myhsok, S. Nickels, S.J. Nyante, C. Olswold, K. Overvad, D. Palli, D.J. Park, J.R. Palmer, H. Pathak, J. Peto, P. Pharoah, N. Rahman, F. Rivadeneira, D.F. Schmidt, R.K. Schmutzler, S. Slager, M.C. Southey, K.N. Stevens, H.P. Sinn, M.F. Press, E. Ross, E. Riboli, P.M. Ridker, F.R. Schumacher, G. Severi, I. Dos Santos Silva, J. Stone, M. Sund, W.J. Tapper, M.J. Thun, R.C. Travis, C. Turnbull, A.G. Uitterlinden, Q. Waisfisz, X. Wang, Z. Wang, J. Weaver, R. Schulz-Wendtland, L.R. Wilkens, D. Van Den Berg, W. Zheng, R.G. Ziegler, E. Ziv, H. Nevanlinna, D.F. Easton, D.J. Hunter, B.E. Henderson, S.J. Chanock, M. Garcia-Closas, P. Kraft, C.A. Haiman and C.M. Vachon. Hum Mol Genet.

(2012) BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk.

Spurdle, A.B., P.J. Whiley, B. Thompson, B. Feng, S. Healey, M.A. Brown, C. Pettigrew, kConFab, C.J. Van Asperen, M.G. Ausems, A.A. Kattentidt-Mouravieva, A.M. van den Ouweland, U.V.C. Dutch Belgium, A. Lindblom, M.H. Pigg, R.K. Schmutzler, C. Engel, A. Meindl, B. German Consortium of Hereditary, C. Ovarian, S. Caputo, O.M. Sinilnikova, R. Lidereau, C.g.c. French, F.J. Couch, L. Guidugli, T. Hansen, M. Thomassen, D.M. Eccles, K. Tucker, J. Benitez, S.M. Domchek, A.E. Toland, E.J. Van Rensburg, B. Wappenschmidt, A. Borg, M.P. Vreeswijk, D.E. Goldgar, and E. Consortium. J Med Genet, 49(8): p. 525-32.

(2012) 19p13.1 is a triple-negative-specific breast cancer susceptibility locus.

Stevens, K.N., Z. Fredericksen, C.M. Vachon, X. Wang, S. Margolin, A. Lindblom, H. Nevanlinna, D. Greco, K. Aittomaki, C. Blomqvist, J. Chang-Claude, A. Vrieling, D. Flesch-Janys, H.P. Sinn, S. Wang-Gohrke, S. Nickels, H. Brauch, G. Network, Y.D. Ko, H.P. Fischer, R.K. Schmutzler, A. Meindl, C.R. Bartram, S. Schott, C. Engel, A.K. Godwin, J. Weaver, H.B. Pathak, P. Sharma, H. Brenner, H. Muller, V. Arndt, C. Stegmaier, P. Miron, D. Yannoukakos, A. Stavropoulou, G. Fountzilas, H.J. Gogas, R. Swann, M. Dwek, A. Perkins, R.L. Milne, J. Benitez, M.P. Zamora, J.I. Perez, S.E. Bojesen, S.F. Nielsen, B.G. Nordestgaard, H. Flyger, P. Guenel, T. Truong, F. Menegaux, E. Cordina-Duverger, B. Burwinkel, F. Marme, A. Schneeweiss, C. Sohn, E. Sawyer, I. Tomlinson, M.J. Kerin, J. Peto, N. Johnson, O. Fletcher, I. Dos Santos Silva, P.A. Fasching, M.W. Beckmann, A. Hartmann, A.B. Ekici, A. Lophatananon, K. Muir, P. Puttawibul, S. Wiangnon, M.K. Schmidt, A. Broeks, L.M. Braaf, E.H. Rosenberg, J.L. Hopper, C. Apicella, D.J. Park, M.C. Southey, A.J. Swerdlow, A. Ashworth, N. Orr, M.J. Schoemaker, H. Anton-Culver, A. Ziogas, L. Bernstein, C.C. Dur, C.Y. Shen, J.C. Yu, H.M. Hsu, C.N. Hsiung, U. Hamann, T. Dunnebier, T. Rudiger, H.U. Ulmer, P.P. Pharoah, A.M. Dunning, M.K. Humphreys, Q. Wang, A. Cox, S.S. Cross, M.W. Reed, P. Hall, K. Czene, C.B. Ambrosone, F. Ademuyiwa, H. Hwang, D.M. Eccles, M. Garcia-Closas, J.D. Figueroa, M.E. Sherman, J. Lissowska, P. Devilee, C. Seynaeve, R.A. Tollenaar, M.J. Hooning, I.L. Andrulis, J.A. Knight, G. Glendon, A.M. Mulligan, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, M. Grip, E.M. John, A. Miron, G.G. Alnaes, V. Kristensen, A.L. Borresen-Dale, G.G. Giles, L. Baglietto, C.A. McLean, G. Severi, M.L. Kosel, V.S. Pankratz, S. Slager, J.E. Olson, P. Radice, P. Peterlongo, S. Manoukian, M. Barile, D. Lambrechts, S. Hatse, A.S. Dieudonne, M.R. Christiaens, G. Chenevix-Trench, I. kConFab, A. Group, J. Beesley, X. Chen, A. Mannermaa, V.M. Kosma, J.M. Hartikainen, Y. Soini, D.F. Easton and F.J. Couch. Cancer Res, 72(7): p. 1795-803.

(2012) Analysis of 30 Putative BRCA1 Splicing Mutations in Hereditary Breast and Ovarian Cancer Families Identifies Exonic Splice Site Mutations That Escape In Silico Prediction.

Wappenschmidt, B., A.A. Becker, J. Hauke, U. Weber, S. Engert, J. Kohler, K. Kast, N. Arnold, K. Rhiem, E. Hahnen, A. Meindl, and R.K. Schmutzler. PLoS One, 7(12): p. e50800.

(2012) Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction PLoS One, 7(12): p. e50800.

Wappenschmidt B, B.A., Hauke J, Weber U, Engert S, Köhler J, Kast K, Arnold N, Rhiem K, Hahnen E, Meindl A, Schmutzler RK.

(2012) 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium.

Warren, H., F. Dudbridge, O. Fletcher, N. Orr, N. Johnson, J.L. Hopper, C. Apicella, M.C. Southey, M. Mahmoodi, M.K. Schmidt, A. Broeks, S. Cornelissen, L.M. Braaf, K.R. Muir, A. Lophatananon, A. Chaiwerawattana, S. Wiangnon, P.A. Fasching, M.W. Beckmann, A.B. Ekici, R. Schulz-Wendtland, E.J. Sawyer, I. Tomlinson, M. Kerin, B. Burwinkel, F. Marme, A. Schneeweiss, C. Sohn, P. Guenel, T. Truong, P. Laurent-Puig, C. Mulot, S.E. Bojesen, S.F. Nielsen, H. Flyger, B.G. Nordestgaard, R.L. Milne, J. Benitez, J.I. Arias-Perez, M.P. Zamora, H. Anton-Culver, A. Ziogas, L. Bernstein, C.C. Dur, H. Brenner, H. Muller, V. Arndt, A. Langheinz, A. Meindl, M. Golatta, C.R. Bartram, R.K. Schmutzler, H. Brauch, C. Justenhoven, T. Bruning, G.N. for The, J. Chang-Claude, S. Wang-Gohrke, U. Eilber, T. Dork, P. Schurmann, M. Bremer, P. Hillemanns, H. Nevanlinna, T.A. Muranen, K. Aittomaki, C. Blomqvist, N. Bogdanova, N. Antonenkova, Y. Rogov, M. Bermisheva, D. Prokofyeva, G. Zinnatullina, E. Khusnutdinova, A. Lindblom, S. Margolin, A. Mannermaa, V.M. Kosma, J.M. Hartikainen, V. Kataja, G. Chenevix-Trench, J. Beesley, X. Chen, I. for kConFab, G. Australian Ovarian Cancer Study, D. Lambrechts, A. Smeets, R. Paridaens, C. Weltens, D. Flesch-Janys, K. Buck, S. Behrens, P. Peterlongo, L. Bernard, S. Manoukian, P. Radice, F.J. Couch, C. Vachon, X. Wang, J. Olson, G. Giles, L. Baglietto, C.A. McLean, G. Severi, E.M. John, A. Miron, R. Winqvist, K. Pylkas, A. Jukkola-Vuorinen, M. Grip, I.L. Andrulis, J.A. Knight, A.M. Mulligan, N. Weerasooriya, P. Devilee, R.A. Tollenaar, J.W. Martens, C.M. Seynaeve, M.J. Hooning, A. Hollestelle, A. Jager, M.M. Tilanus-Linthorst, P. Hall, K. Czene, J. Liu, J. Li, A. Cox, S.S. Cross, I.W. Brock, M.W. Reed, P. Pharoah, F.M. Blows, A.M. Dunning, M. Ghoussaini, A. Ashworth, A. Swerdlow, M. Jones, M. Schoemaker, D.F. Easton, M. Humphreys, Q. Wang, J. Peto and I. Dos-Santos-Silva. Cancer Epidemiol Biomarkers Prev, 21(10): p. 1783-1791.